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A 922500
- Optical Purity: 97% d.e.
- Soluble in DMSO
- MF: C26H24N2O4
- MW: 428.48
Description
A 922500 is a highly potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor with nanomolar activity. It blocks the final step of triacylglycerol synthesis catalyzed by DGAT1.
DGAT1 regulates triglyceride biosynthesis, lipid absorption and energy storage. A 922500 is useful for studying lipid metabolism, intestinal fat handling and metabolic disease mechanisms involving triglyceride synthesis.
Key Features
- Potent selective DGAT1 inhibitor
- Nanomolar activity reported for DGAT1 inhibition
- Blocks triacylglycerol synthesis
- Relevant to lipid metabolism and obesity research
Applications
- DGAT1 enzyme assays
- Triglyceride biosynthesis studies
- Metabolic disease models
- Lipid absorption and storage research
More Information
| Parent CAS No. | 959122-11-3 |
|---|---|
| Chemical Name | (1R,2R)-2-(4'-(3-phenylureido)biphenylcarbonyl)cyclopentanecarboxylic acid |
| SMILES | [C@@H]1(C(O)=O)CCC[C@H]1C(C1=CC=C(C2=CC=C(NC(NC3=CC=CC=C3)=O)C=C2)C=C1)=O |&1:0,7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1 |
| InChiKey | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
| CID | 24768261 |
| Short Description | DGAT-1 inhibitor |
References
- G Zhao et al. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J. Med. Chem. 2008, 51(3), 380-383.
- AJ King et al. Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster. J. Pharmacol. Exp. Ther. 2009, 330(2), 526-531.
- AJ King et al. In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur. J. Pharmacol. 2010, 637(1-3), 155-161.
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