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Remodelin
Axon 2299
CAS:
949912-58-7
Purity:
99%
- Soluble in DMSO
- MF: C15H14N4S
- MW: 282.36
Description
Remodelin is a NAT10 acetyltransferase inhibitor that rescues abnormal nuclear shape in laminopathic cells through microtubule reorganization. It reduces misshapen nuclei in LMNA-depleted cells, Hutchinson-Gilford progeria syndrome cells and aged primary fibroblasts.
NAT10 links acetyltransferase biology to nuclear architecture, laminopathy phenotypes and microtubule-dependent nuclear mechanics. Remodelin is useful for studying nuclear-shape rescue, progeroid cell biology and chromatin-associated stress mechanisms.
Key Features
- NAT10 acetyltransferase inhibitor
- Rescues nuclear-shape defects in laminopathic cells
- Acts through microtubule reorganization
- Active in HGPS and aged fibroblast models
Applications
- Laminopathy and HGPS research
- Nuclear architecture studies
- NAT10 pharmacology
- Microtubule-dependent nuclear-shape assays
More Information
| Parent CAS No. | 949912-58-7 |
|---|---|
| Chemical Name | 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile |
| SMILES | C(#N)C1=CC=C(C2=CSC(N/N=C3CCCC3)=N2)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19) |
| InChiKey | XAEJIFARBQJLML-UHFFFAOYSA-N |
| CID | 44442376 |
| Short Description | NAT 10 inhibitor |
Remodelin
NAT10 acetyltransferase inhibitor
Histone
Chromatin
Laminopathic
Hutchinson-Gilford progeria syndrome
HGPS
NAT10 acetyltransferase
Inhibitor
Laminopathy and HGPS research
Nuclear architecture studies
NAT10 pharmacology
Microtubule-dependent nuclear-shape assays
fibrosis
enzyme pharmacology
drug discovery
Axon Medchem
Axon 2299
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