Acyltransferases

The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.


[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.

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Axon ID Name Description From price
1785 MG 149 HAT inhibitor (Tip60 and MOZ specific) €90.00
1762 PNU 100480 Ribosomal peptidyl transferase center (PTC) inhibitor €60.00
2299 Remodelin Potent NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic cells via microtubule reorganization €90.00
2035 RU-SKI 43 hydrochloride Hedgehog acyltransferase (HHAT) inhibitor blocks Shh signaling €105.00
2673 RUSKI-201 dihydrochloride Sonic HHAT inhibitor lacking off-target cytotoxicity €135.00
2606 Solithromycin Fluoroketolide antibiotic €135.00
2835 SPT Imidazopyridine 1 Potent serine palmitoyl transferase (SPT) inhibitor €120.00
2339 TH 1834 Tip60 histone acetyltransferase inhibitor €135.00
2969 WM-1119 Highly potent and selective KAT6A inhibitor €125.00
2287 Wnt-C59 Highly potent porcupine (Porcn) inhibitor €75.00

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