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KKL-35
- Soluble in DMSO
- MF: C15H9ClFN3O2
- MW: 317.7
Description
KKL-35 is ribosome rescue (trans-translation) inhibitor with an IC50 value of 0.9 µM. KKL-35 exhibits broad-spectrum antibiotic activity.
More Information
| Parent CAS No. | 865285-29-6 |
|---|---|
| Chemical Name | 4-Chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide |
| SMILES | C1C(C(NC2=NN=C(C3C=CC(F)=CC=3)O2)=O)=CC=C(Cl)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C15H9ClFN3O2/c16-11-5-1-9(2-6-11)13(21)18-15-20-19-14(22-15)10-3-7-12(17)8-4-10/h1-8H,(H,18,20,21) |
| InChiKey | ZIICPNCCHIUJSX-UHFFFAOYSA-N |
| CID | 4128171 |
| Short Description | Ribosome rescue inhibitor |
References
- NS Ramadoss et al. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7.
- JN Alumasa et al. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017 Sep 8;3(9):634-644.
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