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PF-04753299
- PF-4753299 - LpxC inhibitor 1a
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C18H21NO4S
- MW: 347.43
Description
PF-04753299 is a potent LpxC inhibitor with reported IC50 activity of 1.37 nM. It inhibits UDP-3-O-acyl-N-acetylglucosamine deacetylase, a key enzyme in lipid A biosynthesis.
LpxC is essential for lipopolysaccharide formation in Gram-negative bacteria and is absent from mammalian cells, making it an important antibacterial drug-discovery target. PF-04753299 is relevant for studying LpxC enzymology, bacterial outer-membrane biogenesis and Gram-negative antibacterial pharmacology.
Key Features
- Potent LpxC inhibitor
- Targets lipid A and lipopolysaccharide biosynthesis
- Relevant to Gram-negative antibacterial research
- Useful tool for bacterial enzyme inhibition studies
Applications
- LpxC enzyme assays
- Gram-negative antibacterial discovery
- Lipid A biosynthesis studies
- Outer-membrane biogenesis research
More Information
| Parent CAS No. | 1289620-49-0 |
|---|---|
| Chemical Name | (R)-4-(biphenyl-4-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide |
| SMILES | C1(C2=CC=CC=C2)=CC=C(CC[C@@](C)(S(=O)(C)=O)C(NO)=O)C=C1 |&1:12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 |
| InChiKey | GDYIQUFNICPYHF-GOSISDBHSA-N |
| CID | 51355576 |
| Short Description | LpxC inhibitor |
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