LpxC

LpxC

Gram-negative bacteria differ from Gram-positive bacteria in that they possess a unique outer membrane, with the outer leaflet of the outer membrane enriched with lipid A, the membrane anchor of lipopolysaccharide (LPS) and the active component of bacterial endotoxin. LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase; EC 3.5.1.108) is a metalloenzyme that catalyzes the first committed step in the biosynthesis of lipid A, an essential component of the outer membrane of Gram-negative bacteria. As such, LpxC is an attractive antibacterial target as there is no human homologue and it is highly conserved in Gram-negative bacteria. The LpxC inhibitors block LPS synthesis by blockade of the sepsis cascade, and show enhanced opsonophagocytic killing of the bacteria.

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    1939
    PF-04753299
    The price depends on the options chosen on the product page

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3 Items

More About LpxC

Gram-negative bacteria differ from Gram-positive bacteria in that they possess a unique outer membrane, with the outer leaflet of the outer membrane enriched with lipid A, the membrane anchor of lipopolysaccharide (LPS) and the active component of bacterial endotoxin[1]. LpxC (UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase; EC 3.5.1.108) is a metalloenzyme that catalyzes the first committed step in the biosynthesis of lipid A, an essential component of the outer membrane of Gram-negative bacteria. As such, LpxC is an attractive antibacterial target as there is no human homologue and it is highly conserved in Gram-negative bacteria. The LpxC inhibitors block LPS synthesis by blockade of the sepsis cascade, and show enhanced opsonophagocytic killing of the bacteria[2].

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