Amidases
Amidases are ubiquitous enzymes and biological functions of these enzymes vary widely. Their proteins structures revealed that aliphatic amidases share the typical a/b hydrolase fold (like nitrilase superfamily) and signature amidases are evolutionary related to aspartic proteinases. They hydrolyze a wide variety of amides (short chain aliphatic amides, mid-chain amides, arylamides, α-aminoamides and α-hydroxyamides) and can be grouped on the basis of their catalytic site and preferred substrate[1].
[1] Amidases: versatile enzymes in nature. M. Sharma, N.N. Sharma, T.C. Bhalla. Rev. Environ. Sci. Biotechnol. 2009, 8, 343-366.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2941 | ARN 272 | Selective inhibitor of FAAH-like anandamide transporter (FLAT) | €90.00 | |
| 3299 | Avibactam sodium | Covalent, reversible inhibitor of β-lactamase | €70.00 | |
| 3747 | BPTES | Potent and selective allosteric GLS inhibitor | €90.00 | |
| 2000 | CHIR090 | Potent and selective LpxC inhibitor | €135.00 | |
| 2113 | PF 05081090 | LpxC inhibitor for treatment of gram-negative infections | €160.00 | |
| 1711 | PF 3845 | Selective fatty acid amide hydrolase (FAAH) inhibitor | €115.00 | |
| 1939 | PF-04753299 | Potent antibacterial LpxC inhibitor (gram-negative infections) | €95.00 | |
| 2041 | Sulbactam sodium | An irreversible inhibitor of β-lactamase | €70.00 | |
| 3820 | Tazobactam acid | Inhibitor of β-lactamase | €50.00 | |
| 3532 | Telaglenastat | Potent, selective, and orally bioavailable glutaminase inhibitor | €70.00 | |
| 4222 | URB597 | Highly potent, selective and orally available FAAH inhibitor | Recently added | €70.00 |
| 3359 | URB937 | Potent, orally available, and peripherally restricted FAAH inhibitor | €80.00 | |