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Telaglenastat
- CB-839
Axon 3532
CAS:
1439399-58-2
Purity:
99%
- Soluble in DMSO
- MF: C26H24F3N7O3S
- MW: 571.57
Description
Telaglenastat is a potent, selective, and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC). Furthermore, Telaglenastat promoted a tumor-specific pharmacodynamic response and had in vivo efficacy in breast cancer xenograft models, both as a single agent and in combination with the standard-of-care agent paclitaxel.
More Information
| Parent CAS No. | 1439399-58-2 |
|---|---|
| Chemical Name | 2-(Pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide |
| SMILES | C1(CCCCC2SC(NC(=O)CC3N=CC=CC=3)=NN=2)N=NC(NC(CC2C=C(OC(F)(F)F)C=CC=2)=O)=CC=1 |
| MFCD | MFCD28167826 |
| InChi | InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38) |
| InChiKey | PRAAPINBUWJLGA-UHFFFAOYSA-N |
| CID | 71577426 |
| Short Description | Glutaminase inhibitor |
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