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BPTES
Axon 3747
CAS:
314045-39-1
Purity:
98%
- Soluble in DMSO
- MF: C24H24N6O2S3
- MW: 524.68
Description
BPTES is a potent and selective allosteric inhibitor of kidney-type glutaminase (GLS) with an IC50 value of 3.3 μM.
More Information
| Parent CAS No. | 314045-39-1 |
|---|---|
| Chemical Name | N,N'-(5,5'-(2,2'-Thiobis(ethane-2,1-diyl))bis(1,3,4-thiadiazole-5,2-diyl))bis(2-phenylacetamide) |
| SMILES | N1=C(NC(=O)CC2C=CC=CC=2)SC(CCSCCC2=NN=C(NC(=O)CC3C=CC=CC=3)S2)=N1 |
| MFCD | MFCD01079848 |
| InChi | InChI=1S/C24H24N6O2S3/c31-19(15-17-7-3-1-4-8-17)25-23-29-27-21(34-23)11-13-33-14-12-22-28-30-24(35-22)26-20(32)16-18-9-5-2-6-10-18/h1-10H,11-16H2,(H,25,29,31)(H,26,30,32) |
| InChiKey | MDJIPXYRSZHCFS-UHFFFAOYSA-N |
| CID | 3372016 |
| Short Description | GLS inhibitor |
References
- MM Robinson et al. Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES). Biochem J. 2007 Sep 15;406(3):407-14.
- K Shukla et al. Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J Med Chem. 2012 Dec 13;55(23):10551-63.
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