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PF 05081090
- PF 5081090
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C18H21FN2O6S
- MW: 412.43
Description
PF 05081090 is a very potent antibacterial LpxC inhibitor with reported Pseudomonas aeruginosa enzyme potency of 1.1 nM. It targets UDP-3-O-acyl-N-acetylglucosamine deacetylase, an essential enzyme in lipid A biosynthesis.
LpxC is a validated antibacterial target in Gram-negative bacteria because lipid A is required for lipopolysaccharide and outer-membrane integrity. PF 05081090 is relevant for serious Gram-negative infection research and LpxC inhibitor profiling.
Key Features
- Potent LpxC inhibitor
- Targets lipid A biosynthesis
- Nanomolar activity against Pseudomonas aeruginosa LpxC
- Relevant to Gram-negative antibacterial discovery
Applications
- LpxC enzyme assays
- Gram-negative antibacterial research
- Lipopolysaccharide biosynthesis studies
- Pseudomonas infection model development
More Information
| Parent CAS No. | 1312473-63-4 |
|---|---|
| Chemical Name | (R)-4-(4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide |
| extra_info | . |
| SMILES | C(NO)(=O)[C@](C)(S(C)(=O)=O)CCN1C(=O)C=C(C2=CC=C(OC)C=C2F)C=C1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H21FN2O6S/c1-18(17(23)20-24,28(3,25)26)7-9-21-8-6-12(10-16(21)22)14-5-4-13(27-2)11-15(14)19/h4-6,8,10-11,24H,7,9H2,1-3H3,(H,20,23)/t18-/m1/s1 |
| InChiKey | DNVUWHWBCMGQLU-GOSISDBHSA-N |
| CID | 56964907 |
| Short Description | LpxC inhibitor |
References
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