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IMD-0354
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C15H8ClF6NO2
- MW: 383.67
Description
IMD-0354 is a cell-permeable inhibitor of IκB kinase β (IKKβ/IKK2) that suppresses IκBα phosphorylation and subsequent NF-κB nuclear translocation. It reduces TNF-α-induced NF-κB signaling and downstream production of inflammatory mediators such as IL-1β and MCP-1.
IMD-0354 is used to study canonical NF-κB pathway function in inflammation, cardiovascular injury, mast-cell signaling and cancer-cell proliferation. Reported cellular effects include attenuation of inflammatory responses, G0/G1 cell-cycle arrest and apoptosis in selected tumor-cell models.
Key Features
- IKKβ/IKK2 pathway inhibitor
- Blocks canonical NF-κB activation
- Reduces inflammatory cytokine and chemokine production
- Cell-permeable signaling probe
Applications
- IKKβ kinase & NF-κB signaling assays
- Inflammation & Cytokine studies
- Cardiovascular injury models
- Cancer cell-cycle & Apoptosis research
More Information
| Parent CAS No. | 978-62-1 |
|---|---|
| Chemical Name | N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide |
| SMILES | C1C(O)=C(C(=O)NC2C=C(C(F)(F)F)C=C(C(F)(F)F)C=2)C=C(Cl)C=1 |
| MFCD | MFCD00218820 |
| InChi | InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25) |
| InChiKey | CHILCFMQWMQVAL-UHFFFAOYSA-N |
| CID | 5081913 |
| Short Description | IKK-2 inhibitor |
References
- Y Onai et al. Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res. 2004 Jul 1;63(1):51-9.
- A Tanaka et al. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 Mar 15;105(6):2324-31.
- A Tanaka et al. A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 2006 Jan 1;66(1):419-26.
- R Hamaya et al. A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice. Int Heart J. 2012;53(2):133-8.
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