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MRT 67307
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H36N6O2
- MW: 464.6
Description
MRT 67307 is an inhibitor of IKKϵ and TBK1 with IC50 values of 160 nM and 19 nM, respectively. MRT 67307 also inhibited the MARK, NUAK, and SIK isoforms in vitro with comparable potency to the IKK-related kinases.
More Information
| Parent CAS No. | 1190378-57-4 |
|---|---|
| Chemical Name | N-(3-(5-Cyclopropyl-2-(3-(morpholinomethyl)phenylamino)pyrimidin-4-ylamino)propyl)cyclobutanecarboxamide |
| SMILES | N1C(NC2C=CC=C(CN3CCOCC3)C=2)=NC(NCCCNC(=O)C2CCC2)=C(C2CC2)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31) |
| InChiKey | UKBGBACORPRCGG-UHFFFAOYSA-N |
| CID | 44464263 |
| Short Description | TBK1/IKKϵ inhibitor |
References
- K Clark et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
- K Clark et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
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