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GSK 8612

Axon 3007
CAS:  2361659-62-1
Purity:  99%
  • Soluble in DMSO
  • MF:  C17H17BrF3N7O2S
  • MW:  520.33

Description

GSK 8612 is a potent and highly selective TBK1 inhibitor (pIC50 value of 6.8). In cellular assays, GSK 8612 inhibited toll-like receptor (TLR)3-induced interferon regulatory factor (IRF)3 phosphorylation in Ramos cells and type I interferon (IFN) secretion in primary human mononuclear cells. In THP1 cells, GSK 8612 was able to inhibit secretion of interferon beta (IFNβ) in response to dsDNA and cGAMP, the natural ligand for STING.

More Information

Certificate of Analysis (B2)
Material Safety Data Sheet (B2)

Certificate of Analysis

B1

Material Safety Data Sheet

B1
Parent CAS No. 2361659-62-1
Chemical Name 4-((5-Bromo-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-ylamino)pyrimidin-4-ylamino)methyl)benzenesulfonamide
SMILES C1C=C(CNC2C(Br)=CN=C(NC3C(C)=NN(CC(F)(F)F)C=3)N=2)C=CC=1S(=O)(=O)N
MFCD N.A.
InChi InChI=1S/C17H17BrF3N7O2S/c1-10-14(8-28(27-10)9-17(19,20)21)25-16-24-7-13(18)15(26-16)23-6-11-2-4-12(5-3-11)31(22,29)30/h2-5,7-8H,6,9H2,1H3,(H2,22,29,30)(H2,23,24,25,26)
InChiKey FFPHMUIGESPOTK-UHFFFAOYSA-N
CID 137553174
Short Description TBK1 inhibitor

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