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JNJ0966
- Soluble in DMSO
- MF: C16H16N4O2S2
- MW: 360.45
Description
JNJ0966 is a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme (IC50 value of 440 nM). JNJ0966 had no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen.
More Information
| Parent CAS No. | 315705-75-0 |
|---|---|
| Chemical Name | N-(2-(2-Methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)acetamide |
| SMILES | C1C=CC=C(OC)C=1NC1SC=C(C2=C(C)N=C(NC(C)=O)S2)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21) |
| InChiKey | ZADCDCMLLGDCRM-UHFFFAOYSA-N |
| CID | 1117189 |
| Short Description | pro-MMP9 inhibitor |
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