Di- and tripeptidyl peptidases (EC 3.4.14.-) make up an individual class of aminopeptidases. DPP4 (EC is also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26). It is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Additionally, it has been proven to be implicated in the pathogenesis of type 2 diabetes[1]

[1] Vildagliptin, a dipetidyl peptidase-IV inhibitor, improves model-assessed β-cell function in patients with type 2 diabetes. A. Mari et al. J. Clin. Endocrinol. Metab. 2005, 90, 4888-4894.

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Axon ID Name Description From price
3310 Alogliptin benzoate Potent, highly selective and orally active DPP-4 inhibitor €65.00
2354 Linagliptin Competitive and highly selective dipeptidyl peptidase (DPP)-4 inhibitor €90.00
3438 NDMC101 DPP-4 inhibitor; Osteoclastogenesis inhibitor €90.00
3251 Sitagliptin Potent, selective and orally active DPP-4 inhibitor €50.00
3309 Teneligliptin hydrobromide Highly potent, selective, long-lasting and orally active DPP-4 inhibitor €50.00
2470 Trelagliptin succinate Orally active DPP4 inhibitor for the treatment of type 2 diabetes €145.00
1631 Vildagliptin DPP4 inhibitor €60.00

7 Item(s)

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