PPP1R15B

PPP1R15B

In mammals, two heterodimeric eIF2α holophosphatases maintain low levels of eIF2α phosphorylation: each comprises a regulatory subunit, the stress-inducible PPP1R15A (R15A), or the constitutive PPP1R15B (R15B), which is bound to the catalytic subunit protein phosphatase 1 (PP1c). This regulatory subunit of protein phosphatase 1, R15B, is a negative regulator of proteostasis.

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More About PPP1R15B

In mammals, two heterodimeric eIF2α holophosphatases maintain low levels of eIF2α phosphorylation: each comprises a regulatory subunit, the stress-inducible PPP1R15A (R15A), or the constitutive PPP1R15B (R15B), which is bound to the catalytic subunit protein phosphatase 1 (PP1c). This regulatory subunit of protein phosphatase 1, R15B, is a negative regulator of proteostasis.[1]

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