Esterases (Phosphomono-)

The family of phosphoprotein phosphatases includes enzymes that dephosphorylate serine, threonine (EC and tyrosine (EC residues within their substrates. Analogous to kinases, some show certain specificity towards Ser/Thr or Tyr residues, like PPM1D (EC Phosphatases that do not show this selectivity are classified as dual-specificity phosphatases (DUSP).
DUSPs have been implicated as major modulators of critical signaling pathways that are dysregulated in various diseases. DUSPs can be divided into six subgroups on the basis of sequence similarity. Of these subgroups, a great deal of research has focused on the characterization of the mitogen-activated protein kinase phosphatases (MKPs)[1]. While DUSP1 has been identified as a prototypic MAPK phosphatase, an essential endogenous regulator of the inflammatory response to lipopolysaccharide (LPS)[2], the DUSP6 functions as a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2[3].

[1] Dual-specificity phosphatases: critical regulators with diverse cellular targets. K.I. Patterson et al. Biochem. J. 2009, , 418, 475-489.
[2] Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. M. Hammer et al. J. Exp. Med. 2006, 203, 15-20.
[3] Dusp6(Mkp3) is a negative feedback regulator of FGF stimulated ERK signaling during mouse development. Chaoying Li. Development. 2007, 134, 167-176.

14 Item(s)

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Axon ID Name Description From price
2178 BCI Allosteric inhibitor of dual-specificity phosphatases (DUSP) €75.00
2852 BCI hydrochloride Allosteric inhibitor of dual-specificity phosphatases (DUSP) €75.00
1821 CCT 007093 Protein phosphatase 1D (PPM1D) inhibitor €95.00
3018 DJ001 Selective, non-competitive, allosteric inhibitor of PTPσ  Recently added €125.00
2480 LW6 Inhibitor of HIF-1α stability via MDH2 inhibition and/or binding with CHP1 €85.00
2702 NQ301 Selective allosteric inhibitor of CD45 €90.00
3004 Raphin1 Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) €105.00
2983 Raphin1 acetate Selective, brain-penetrant, and orally bioavailable inhibitor of PPP1R15B (R15B) €110.00
2963 SBI-425 Potent, selective and orally bioavailable TNAP inhibitor €125.00
2524 Sephin 1 Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity €55.00
2186 SF 1670 Inhibitor of PTEN with significant inhibitory effect on PTPRC and GALK €120.00
2633 SHP099 Highly potent, selective and orally bioavailable SHP2 inhibitor €90.00
2263 Tacrolimus Potent Calcineurin (Ca2+ dependent protein phosphatase 2B) inhibitor €100.00
2723 TPI-1 Selective SHP1 inhibitor €95.00

14 Item(s)

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