SHP

SHP

SHP-2 (EC 3.1.3.48; aka tyrosine-protein phosphatase non-receptor type 11 (PTPN11), protein-tyrosine phosphatase 1D (PTP-1D), or protein-tyrosine phosphatase 2C (PTP-2C)) is a cytoplasmic SH2 (Src-homology 2) domain containing member of the family of protein tyrosine phosphatases (PTP), transducing signal relay from the cell surface to the nucleus. It is ubiquitously expressed and shown to be involved in regulation of cellular development and differentiation, survival, and migration by promoting growth factors-induced activation of PI3K/Akt, the extracellular signal-related kinases (ERKs), NF-κB, JAK2/STAT, and other pathways.

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  • SHP099
    2633
    SHP099
    The price depends on the options chosen on the product page

    From $88.00

  • TPI-1
    2723
    TPI-1
    The price depends on the options chosen on the product page

    From $104.50

  • JAB-3068
    3721
    JAB-3068
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    From $264.00

  • ABBV-CLS-484 hydrochloride
    3729
    ABBV-CLS-484 hydrochloride
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    From Inquiry

  • GDC-1971
    3767
    GDC-1971
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    From Inquiry

  • TNO155
    3865
    TNO155
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    From Inquiry

  • RMC-4550 hydrochloride
    3868
    RMC-4550 hydrochloride
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    From Inquiry

  • IACS-13909 hydrochloride
    3903
    IACS-13909 hydrochloride
    The price depends on the options chosen on the product page

    From Inquiry

8 Items

More About SHP

SHP-2 (EC 3.1.3.48; aka tyrosine-protein phosphatase non-receptor type 11 (PTPN11), protein-tyrosine phosphatase 1D (PTP-1D), or protein-tyrosine phosphatase 2C (PTP-2C)) is a cytoplasmic SH2 (Src-homology 2) domain containing member of the family of protein tyrosine phosphatases (PTP), transducing signal relay from the cell surface to the nucleus[1]. It is ubiquitously expressed and shown to be involved in regulation of cellular development and differentiation, survival, and migration by promoting growth factors-induced activation of PI3K/Akt, the extracellular signal-related kinases (ERKs), NF-κB, JAK2/STAT, and other pathways[2].

[1] CK Qu. The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions. Cell Res. 2000 Dec;10(4):279-88.
[2] J Kiyan et al. The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells. Exp Cell Res. 2009 Apr 1;315(6):1029-39.

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