NF-κB

The NF-κB signaling pathway is involved in a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. A remarkable diversity of stimuli lead to the activation of NF-κB, among which are pro-inflammatory cytokines, LPS, growth factors, and antigen receptors. They activate an IKK complex (IKKβ, IKKα, and NEMO), which phosphorylates IκB proteins. Phosphorylation of IκB leads to its ubiquitination and proteasomal degradation, freeing NF-κB/Rel complexes. Active NF-κB/Rel complexes are further activated by phosphorylation and translocate to the nucleus where, either alone or in combination with other transcription factor families including AP-1, Ets, and Stat, they induce target gene expression[1],[2]. The core elements of NF-κB signaling pathways are generally several steps removed from the receptor itself. The intervening steps between receptor and IKK form links to parallel signaling pathways. For example, PKC enzymes play important roles in several signal transduction cascades. In NF-κB signaling, PKC-β connects the B cell receptor to canonical activation of NF-κB through a signaling complex, including Bcl10/MALT1 and NEMO/IKKγ[3].


[1] M.S. Hayden, S. Ghosh. Shared principles in NF-kappaB signaling. Cell. 2008, 132, 344-362.
[2]  Rel/NF-κB Transcription Factors. Gilmore TD. http://www.bu.edu/nf-kb/ 2008.
[3] Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo. G. Lutzny et al. Cancer Cell. 2013, 23, 77-92.

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Axon ID Name Description From price
2175 3PO Inhibitor of HIF-1-induced PFKFB3, an enzyme with a key role in glycolysis. €65.00
2552 Adjudin Non-hormonal male contraceptive with anti-proliferative activity €125.00
1291 AEG 3482 JNK inhibitor €85.00
2500 Apilimod mesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor Inquire
2611 APS-2-79 Inhibitor of KSR and oncogenic Ras signaling €90.00
2307 ARM1 hydrobromide Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 €92.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
2132 BAY 11-7082 IKK inhibitor and anti-inflammatory €85.00
2178 BCI Allosteric inhibitor of dual-specificity phosphatases (DUSP) €75.00
1731 BMS 345541 Cell-permeable and selective IKB (IKK) inhibitor €105.00
1390 BX 795 PDPK1, TBK1 and IKK inhibitor €65.00
2575 C-DIM12 Nurr1 activator that stimulates apoptosis in bladder cancer cells €85.00
2025 CC 401 ATP-competitive JNK inhibitor €145.00
2634 CC-930 Potent, selective, and orally active anti-fibrotic JNK inhibitor €105.00

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