IACS-13909 hydrochloride
Axon 3903
- Parent CAS: 2160546-07-4
Purity:
99%
- Soluble in water and DMSO
- MF: C17H18Cl2N6.HCl
- MW: 413.73
Description
IACS-13909 is a potent and specific allosteric inhibitor of SHP2, suppressing the signaling of RTK/MAPK pathway. IACS-13909 potently impedes the proliferation of tumors with a broad spectrum of RTKs as the oncogenic driver. Importantly, in NSCLC models with acquired resistance to Osimertinib, IACS-13909 administered as a single agent or in combination with Osimertinib potently reduces tumor cell proliferation in vitro and in vivo, which provide preclinical evidence for using a SHP2 inhibitor as a therapeutic strategy in acquired EGFR inhibitor-resistant NSCLC.
More Information
| Parent CAS No. | 2160546-07-4 |
|---|---|
| Chemical Name | 1-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine hydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12C(C3C=CC=C(Cl)C=3Cl)=NNC=1N=C(N1CCC(N)(C)CC1)C=N2.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C17H18Cl2N6.ClH/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19;/h2-4,9H,5-8,20H2,1H3,(H,22,23,24);1H |
| InChiKey | URILZFHZTIFVFH-UHFFFAOYSA-N |
| CID | 169488013 |
| Short Description | SHP2 inhibitor |
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