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JAB-3068
Axon 3721
CAS:
2169223-48-5
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H26F2N6O2S
- MW: 476.54
Description
JAB-3068 is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 (protein tyrosine phosphatase) (PTP) non-receptor type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity. It is efficacious as an oral monotherapy as well as an immune-oncology modulator.
More Information
| Parent CAS No. | 2169223-48-5 |
|---|---|
| Chemical Name | (S)-1-(4-(3-amino-5-(4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-ylthio)-3,3-difluoroindolin-1-yl)ethanone |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12N(C(=O)C)CC(F)(F)C1=C(SC1N=CC(N3CCC4(COC[C@H]4N)CC3)=NC=1N)C=CC=2 |&1:23,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H26F2N6O2S/c1-13(31)30-11-22(23,24)18-14(30)3-2-4-15(18)33-20-19(26)28-17(9-27-20)29-7-5-21(6-8-29)12-32-10-16(21)25/h2-4,9,16H,5-8,10-12,25H2,1H3,(H2,26,28)/t16-/m1/s1 |
| InChiKey | HGYTYZKWKUXRKA-MRXNPFEDSA-N |
| CID | 132222602 |
| Short Description | SHP2 inhibitor |
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