GDC-1971
- RLY-1971
Axon 3767
CAS:
2377352-49-1
- Optical Purity: 0.98
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C25H26N8O
- MW: 454.53
Description
GDC-1971 is an orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2, binding and stabilizing SHP2 in its inactive conformation.
More Information
| Parent CAS No. | 2377352-49-1 |
|---|---|
| Chemical Name | (R)-1'-(3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12C(N3CCCC4N=CC=CC3=4)=NNC=1N=C(N1CCC3(OC4C=CC=CC=4[C@H]3N)CC1)C=N2 |&1:28,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C25H26N8O/c26-22-16-5-1-2-8-19(16)34-25(22)9-13-32(14-10-25)20-15-28-21-23(29-20)30-31-24(21)33-12-4-6-17-18(33)7-3-11-27-17/h1-3,5,7-8,11,15,22H,4,6,9-10,12-14,26H2,(H,29,30,31)/t22-/m1/s1 |
| InChiKey | RGCGBFIARQENML-JOCHJYFZSA-N |
| CID | 139512018 |
| Short Description | SHP2 inhibitor |
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