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TPI-1
Axon 2723
CAS:
79756-69-7
Purity:
99%
- Soluble in DMSO
- MF: C12H6Cl2O2
- MW: 253.08
Description
SHP1 inhibitor TPI-1 (IC50 value 40 nM) selectively increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action.
More Information
| Parent CAS No. | 79756-69-7 |
|---|---|
| Chemical Name | 2-(2,5-Dichlorophenyl)cyclohexa-2,5-diene-1,4-dione |
| SMILES | C1C(Cl)=C(C2=CC(=O)C=CC2=O)C=C(Cl)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H |
| InChiKey | ZKHFYORNAYYOTM-UHFFFAOYSA-N |
| CID | 948589 |
| Short Description | SHP1 inhibitor |
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