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NQ301
- Compound 211
- Soluble in DMSO
- MF: C18H12ClNO3
- MW: 325.75
Description
NQ301 (Compound 211), also known as Compound 211, is an allosteric, noncompetitive inhibitor of the leukocyte protein tyrosine phosphatase CD45 (PTPRC), with a reported IC50 of approximately 200–290 nM. It shows more than 200-fold selectivity over a panel of related protein tyrosine phosphatases and suppresses T-cell receptor signaling by increasing inhibitory phosphorylation of the Src-family kinase Lck.
NQ301 reduces T-cell activation and inflammation in cellular and delayed-type hypersensitivity models. Independently, it displays antiplatelet and antithrombotic activity by inhibiting thromboxane A2 receptor signaling and thromboxane synthase activity in rabbit platelets. These dual pharmacological profiles make NQ301 useful for CD45-dependent immune signaling as well as platelet and thromboxane-pathway research.
Key Features
- Allosteric CD45 phosphatase inhibitor
- IC50: approximately 200–290 nM
- More than 200-fold selective over related protein tyrosine phosphatases
- Suppresses Lck-dependent T-cell receptor signaling
- Also inhibits platelet thromboxane signaling
Applications
- CD45/PTPRC phosphatase biology
- T-cell receptor signaling and immune activation
- Src-family kinase and Lck regulation
- Inflammation and delayed-type hypersensitivity models
- Platelet aggregation and thromboxane A2 research
More Information
| Parent CAS No. | 130089-98-4 |
|---|---|
| Chemical Name | 2-(4-Acetylphenylamino)-3-chloronaphthalene-1,4-dione |
| SMILES | C1C=C2C(=O)C(NC3C=CC(C(=O)C)=CC=3)=C(Cl)C(=O)C2=CC=1 |
| MFCD | MFCD00559986 |
| InChi | InChI=1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3 |
| InChiKey | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
| CID | 781109 |
| Short Description | CD45 inhibitor |
References
- WS Kang et al. Antiplatelet and antithrombotic activities of NQ301, 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone. Biol Pharm Bull. 1999 Dec;22(12):1284-7.
- YH Zhang et al. Antiplatelet effect of 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone (NQ301): a possible mechanism through inhibition of intracellular Ca2+ mobilization. Biol Pharm Bull. 2001 Jun;24(6):618-22.
- YR Jin et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):162-7.
- MD Perron et al. Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol Pharmacol. 2014 Apr;85(4):553-63.
