Bulk Inquiry
Sephin 1
- NSC 65390
- Soluble in DMSO
- MF: C8H9ClN4
- MW: 196.64
Description
Sephin 1 (NSC65390) is reported as a selective inhibitor of PPP1R15A/GADD34-mediated eIF2α dephosphorylation. It prolongs integrated stress response signaling by disrupting the PPP1R15A-PP1c complex.
PPP1R15A controls recovery from cellular stress by recruiting protein phosphatase 1 to dephosphorylate eIF2α. Sephin 1 is used to study proteostasis, ER stress and integrated stress response pathways, while interpretation should consider ongoing discussion around its direct target engagement.
Key Features
- Reported PPP1R15A/GADD34 pathway inhibitor
- Prolongs eIF2α phosphorylation in stress-response models
- Reported selectivity over PPP1R15B-mediated signaling
- Modulates integrated stress response recovery
Applications
- Integrated stress response research
- ER stress and proteostasis studies
- eIF2α phosphorylation assays
- Neurodegeneration and protein-misfolding models
More Information
| Parent CAS No. | 951441-04-6 |
|---|---|
| Chemical Name | (E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide |
| SMILES | N(C(N)=N)/N=C/C1=CC=CC=C1Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+ |
| InChiKey | PDWJALXSRRSUHR-LFYBBSHMSA-N |
| CID | 9561611 |
| Short Description | PPP1R15A inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1821 | CCT 007093 |
From $104.50 |
| 2178 | BCI |
From $82.50 |
| 2186 | SF 1670 |
From $132.00 |
| 2263 | Tacrolimus |
From $110.00 |
| 2633 | SHP099 |
From $88.00 |
| 2963 | SBI-425 |
From $137.50 |
| 2983 | Raphin1 acetate |
From $121.00 |
| 3004 | Raphin1 |
From $115.50 |
| 4249 | Salubrinal |
From $121.00 |
