PPP1R15A

PPP1R15A

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A; also known as growth arrest and DNA damage-inducible protein GADD34) is a member of the protein family whose expression is up-regulated by growth arrest and DNA damage. It recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. PPP1R15a down-regulates the TGF-β signaling pathway by promoting dephosphorylation of TGFB1 by PP1, and may promote apoptosis by inducing TP53 phosphorylation on Ser-15.

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More About PPP1R15A

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A; also known as growth arrest and DNA damage-inducible protein GADD34) is a member of the protein family whose expression is up-regulated by growth arrest and DNA damage. It recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress[1]. PPP1R15a down-regulates the TGF-β signaling pathway by promoting dephosphorylation of TGFB1 by PP1, and may promote apoptosis by inducing TP53 phosphorylation on Ser-15[2].

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