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BCI hydrochloride
- NSC 150117 hydrochloride
- Parent CAS: 1245792-51-1
- Soluble in DMSO
- MF: C22H23NO.HCl
- MW: 353.89
Description
BCI hydrochloride is the hydrochloride salt of BCI (NSC 150117, Axon 2178), an allosteric inhibitor of dual-specificity phosphatases (DUSPs). BCI selectively inhibits DUSP6 and DUSP1 with IC50 values of 12.3 μM and 11.5 μM, respectively, while showing no significant inhibition of DUSP5.
DUSP6 is a key feedback regulator of fibroblast growth factor (FGF) signaling that negatively regulates ERK1/2 activation. Pharmacological inhibition of DUSP6 by BCI enhances ERK signaling and has been widely used to study developmental biology, regeneration, stem cell signaling, and cancer biology. BCI-mediated DUSP6 inhibition promotes expansion of myocardial progenitor cells and increases heart size in zebrafish embryos. In addition, BCI has demonstrated activity against lung cancer and uveal melanoma cell lines.
- Allosteric inhibitor of DUSP6 and DUSP1
- IC50: 12.3 μM (DUSP6) and 11.5 μM (DUSP1)
- Enhances ERK signaling through DUSP6 inhibition
- Useful tool for developmental, regeneration, and cancer research
Applications
- DUSP6 and DUSP1 signaling research
- FGF-ERK pathway investigations
- Developmental biology and regenerative medicine studies
- Cardiac development and myocardial progenitor research
- Cancer biology and target validation studies
Related Products
BCI free base (Axon 2178) is also available. Researchers seeking an optimized second-generation DUSP inhibitor may consider BCI-215 (Axon 4452), a refined analogue developed to further investigate DUSP-dependent signaling pathways.
More Information
| Parent CAS No. | 1245792-51-1 |
|---|---|
| Chemical Name | 2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one hydrochloride |
| SMILES | C1C=C2C(=O)/C(=C/C3C=CC=CC=3)/C(NC3CCCCC3)C2=CC=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H/b20-15+; |
| InChiKey | JPATUDRDKCLPTI-QMGGKDRNSA-N |
| CID | 69670465 |
| Short Description | DUSP inhibitor |
References
- G. Molina et al. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat. Chem. Biol. 2009, 5, 680-687.
- A.M. Best et al. Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay. J. Biomed. Biotechnol. 2011, 868095.
