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NSC 95397
Axon 3086
CAS:
93718-83-3
Purity:
98%
- Soluble in DMSO
- MF: C14H14O4S2
- MW: 310.39
Description
NSC 95397 is a potent and selective Cdc25 dual specificity phosphatase (DUSP) inhibitor with in vitro Ki values of 32, 96, and 40 nM for Cdc25A, -B, and -C, respectively. NSC 95397 was 125- to 180-fold more selective for Cdc25A than VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b, respectively. Moreover, NSC 95397 showed significant growth inhibition against human and murine carcinoma cells and blocked G(2)/M phase transition.
More Information
| Parent CAS No. | 93718-83-3 |
|---|---|
| Chemical Name | 2,3-Bis(2-hydroxyethylthio)naphthalene-1,4-dione |
| SMILES | C1C2C(=O)C(SCCO)=C(SCCO)C(=O)C=2C=CC=1 |
| MFCD | MFCD04040032 |
| InChi | InChI=1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2 |
| InChiKey | MAASHDQFQDDECQ-UHFFFAOYSA-N |
| CID | 262093 |
| Short Description | Cdc25 inhibitor |
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