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BCI-215
Axon 4452
CAS:
1245792-67-9
Purity:
99%
- Soluble in DMSO
- MF: C22H22BrNO
- MW: 396.32
Description
BCI-215 is a potent DUSP inhibitor which exhibited similar activity to parent compound BCI (Axon 2178) but lacked organismal or cellular toxicity.
More Information
| Parent CAS No. | 1245792-67-9 |
|---|---|
| Chemical Name | (E)-5-Bromo-3-(cyclohexylamino)-2-phenylmethylene-1-indanone |
| Short Description | DUSP inhibitor |
References
- V Ecker et al. Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Rep. 2023 Oct 31;42(10):113017.
- VN Korotchenko et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.
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