BCI - NSC 150117

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2178

CAS [1245792-51-1]

MW 317.42

  • Purity: 99%
  • Soluble in DMSO



Allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc–transfected cells blocks DUSP6 or DUSP1 activity, but not DUSP5 (IC50 values 12.3 μM and 11.5 μM for DUSP6 and DUSP1 inhibition, resp.). BCI mediated DUSP6 inhibition can induce expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos.BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM).The dual-specificity phosphatase 6 (DUSP6) functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.

The more hydrophilic BCI hydrochloride (Axon 2852) is also available.

KEYWORDS: BCI | supplier | DUSP inhibitor | NSC 150117 | NSC150117 | NSC-150117 | CAS [1245792-51-1] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | DUSP | Inhibitor | Enzymes

Size Unit Price Stock
10 mg €75.00 In Stock
50 mg €180.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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