JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website.
There are no items in your shopping cart
Featured Products
Axon 2178
CAS [1245792-51-1]
MF C22H23NOMW 317.42
Allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc–transfected cells blocks DUSP6 or DUSP1 activity, but not DUSP5 (IC50 values 12.3 μM and 11.5 μM for DUSP6 and DUSP1 inhibition, resp.). BCI mediated DUSP6 inhibition can induce expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos.BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM).The dual-specificity phosphatase 6 (DUSP6) functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.
The more hydrophilic BCI hydrochloride (Axon 2852) is also available.
KEYWORDS: BCI | supplier | DUSP inhibitor | NSC 150117 | NSC150117 | NSC-150117 | CAS [1245792-51-1] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | DUSP | Inhibitor | Enzymes
2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
[1245792-51-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
* Required Fields