Allosteric inhibitor of dual-specificity phosphatases (DUSP). BCI treatment of DUSP6-Myc–transfected cells blocks DUSP6 or DUSP1 activity, but not DUSP5 (IC50 values 12.3 μM and 11.5 μM for DUSP6 and DUSP1 inhibition, resp.). BCI mediated DUSP6 inhibition can induce expansion of myocardial progenitors that ultimately increases heart size in zebrafish embryos.BCI also inhibits lung cancer and uveal melanoma cells viability (IC50 values ranging from 0.1 to 90 μM).The dual-specificity phosphatase 6 (DUSP6) functions a feedback regulator of fibroblast growth factor (FGF) signaling to limit the activity of extracellular signal–regulated kinases (ERKs) 1 and 2.

The more hydrophilic BCI hydrochloride (Axon 2852) is also available.

KEYWORDS: BCI | supplier | DUSP inhibitor | NSC 150117 | NSC150117 | NSC-150117 | CAS [1245792-51-1] | Non Selective (Serine-Threonine and Tyrosine Specific Phosphodiesters) | DUSP | Inhibitor | Enzymes