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RO 28-1675
- (R)-RO 28-0450
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C18H22N2O3S2
- MW: 378.51
Description
RO 28-1675 is a potent allosteric glucokinase activator with a reported EC50 value of 54 nM. It is the pharmacologically more active R-enantiomer of RO 28-0450 (Axon 1134) in comparison with S-enantiomer, RO 28-1674 (Axon 1355).
RO 28-1675 increases glucokinase glucose affinity and catalytic capacity, enhancing glucose-stimulated insulin secretion in pancreatic islets and glucose utilization in hepatocytes. It is a benchmark tool for glucose-sensing and metabolic disease research.
Key Features
- Potent allosteric glucokinase activator
- Reported EC50: 54 nM
- Increases glucokinase glucose affinity and Vmax
- More active R-enantiomer of RO 28-0450
Applications
- Glucokinase enzyme and kinetic assays
- Pancreatic β-cell glucose-sensing studies
- Glucose-stimulated insulin secretion research
- Hepatic glucose metabolism and type 2 diabetes models
More Information
| Parent CAS No. | 300353-13-3 |
|---|---|
| Chemical Name | (R)-(-)-3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide |
| SMILES | C1C(S(=O)(C)=O)=CC=C([C@@H](CC2CCCC2)C(=O)NC2SC=CN=2)C=1 |&1:9,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C18H22N2O3S2/c1-25(22,23)15-8-6-14(7-9-15)16(12-13-4-2-3-5-13)17(21)20-18-19-10-11-24-18/h6-11,13,16H,2-5,12H2,1H3,(H,19,20,21)/t16-/m1/s1 |
| InChiKey | NEQSWPCDHDQINX-MRXNPFEDSA-N |
| CID | 9886086 |
| Short Description | GK activator |
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