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Mitapivat
- PKM2 activator 1020
Axon 2149
CAS:
1260075-17-9
Purity:
99%
- Soluble in DMSO
- MF: C24H26N4O3S
- MW: 450.55
Description
Mitapivat is an activator of pyruvate kinase isoenzymes and is commonly used to modulate glycolytic flux through pyruvate kinase activation. The source entry highlights PKM2 activation, an isoform closely associated with proliferating and tumor cells.
Pyruvate kinase controls the final ATP-generating step of glycolysis and links energy metabolism to biosynthesis. Mitapivat is pharmacologically relevant for studying glycolysis, red blood cell metabolism and metabolic vulnerabilities in disease models.
Key Features
- Pyruvate kinase activator
- Modulates glycolytic flux and pyruvate formation
- Relevant to PKM2-associated tumor metabolism
- Clinically important scaffold for pyruvate kinase deficiency research
Applications
- Glycolysis and energy metabolism studies
- Pyruvate kinase activation assays
- Cancer metabolism research
- Red blood cell metabolic disease models
More Information
| Parent CAS No. | 1260075-17-9 |
|---|---|
| Chemical Name | N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide |
| SMILES | C1(C(N2CCN(CC3CC3)CC2)=O)C=CC(NS(C2C3N=CC=CC=3C=CC=2)(=O)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2 |
| InChiKey | XAYGBKHKBBXDAK-UHFFFAOYSA-N |
| CID | 59634741 |
| Short Description | PKM2 activator |
Mitapivat
pyruvate kinase activator
Pyruvate
PKM2
Isoenzyme M2
pyruvate kinase
Iso-enzyme
Activator
Glycolysis and energy metabolism studies
Pyruvate kinase activation assays
Cancer metabolism research
Red blood cell metabolic disease models
cancer biology
metabolism
kinase signaling
drug discovery
CAS 1260075-17-9
Axon Medchem
Axon 2149
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