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3PO
Axon 2175
CAS:
18550-98-6
Purity:
99%
- Soluble in DMSO
- MF: C13H10N2O
- MW: 210.23
Description
3PO is an inhibitor of HIF-1-induced PFKFB3, a glycolytic control enzyme that regulates fructose-2,6-bisphosphate production. It attenuates F2,6BP synthesis, glucose uptake, lactate secretion, TNFα secretion and T cell aggregation/proliferation in reported systems.
PFKFB3 has a high kinase-to-phosphatase activity ratio and supports glycolytic flux in proliferating, immune and tumor cells. 3PO is relevant for studying metabolic control of cancer growth and immune activation.
Key Features
- PFKFB3 glycolysis inhibitor
- Reduces F2,6BP synthesis and glucose uptake
- Suppresses lactate and TNFα-associated outputs
- Useful metabolic tool for tumor and immune cell studies
Applications
- Cancer metabolism research
- Glycolysis pathway assays
- T cell activation and immunometabolism studies
- PFKFB3 inhibitor profiling
More Information
| Parent CAS No. | 18550-98-6 |
|---|---|
| Chemical Name | (E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one |
| SMILES | C(C1C=CN=CC=1)(=O)/C=C/C1=CC=CN=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+ |
| InChiKey | UOWGYMNWMDNSTL-ONEGZZNKSA-N |
| CID | 5720233 |
| Short Description | PFKFB3 inhibitor |
3PO
PFKFB3 glycolysis inhibitor
Fructose 6-phosphate
PFKFB3
F6P
F2
6BP
HIF-1-INDUCED
PFKFB3 glycolysis
Inhibitor
Cancer metabolism research
Glycolysis pathway assays
T cell activation and immunometabolism studies
PFKFB3 inhibitor profiling
immunology
T-cell biology
cancer biology
metabolism
compound synthesis
kinase signaling
CAS 18550-98-6
Axon Medchem
Axon 2175
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