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LDC7559

Axon 3482
CAS:  2407782-01-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C20H19N3O3
  • MW:  349.38

Description

LDC7559 inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening flux through the pentose phosphate pathway. LDC7559 is an inhibitor of NOX2-dependent NETosis with an IC50 value of 3.1 μM.

More Information

Parent CAS No. 2407782-01-6
Chemical Name N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
SMILES C12CN3N=C(C4C=CC=CC=4OC)C=C3COC=1C=C(NC(=O)C)C=C2
MFCD N.A.
InChi InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)
InChiKey IFOIINXSFCQLOV-UHFFFAOYSA-N
CID 138319675
Short Description PFKL activator

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