Bulk Inquiry
NHI 2
Axon 2450
CAS:
1269802-97-2
Purity:
99%
- Soluble in DMSO
- MF: C17H12F3NO3
- MW: 335.28
Description
NHI 2 is a cell-permeable inhibitor of lactate dehydrogenase A (LDH-A) with selectivity over LDH-B. It suppresses glycolytic lactate production and is used to investigate cancer metabolism.
LDH-A supports aerobic glycolysis by converting pyruvate to lactate and regenerating NAD+ in highly glycolytic cells. NHI 2 is useful for studying metabolic reprogramming, Warburg-effect biology and LDH-A-dependent tumor cell viability.
Key Features
- LDH-A inhibitor
- Reported IC50 values: 14.7 µM for LDH-A and 55.8 µM for LDH-B
- Cell-permeable glycolysis-modulating compound
- Reduces LDH-A-dependent lactate pathway activity
Applications
- Cancer metabolism research
- LDH-A enzyme pharmacology
- Glycolysis and Warburg-effect assays
- Metabolic vulnerability studies in tumor cells
More Information
| Parent CAS No. | 1269802-97-2 |
|---|---|
| Chemical Name | methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate |
| SMILES | C1C(C(F)(F)F)=C2C=C(C(OC)=O)N(O)C2=CC=1C1C=CC=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3 |
| InChiKey | YPPFWRWCZNXINO-UHFFFAOYSA-N |
| CID | 51355147 |
| Short Description | LDH-A inhibitor |
NHI 2
LDH-A inhibitor
Lactate
NADH
LDH-A
Inhibitor
Cancer metabolism research
LDH-A enzyme pharmacology
Glycolysis and Warburg-effect assays
Metabolic vulnerability studies in tumor cells
reprogramming
cancer biology
metabolism
receptor selectivity
enzyme pharmacology
drug discovery
apoptosis
CAS 1269802-97-2
Axon Medchem
Axon 2450
Supplier
Vendor
References
- C Granchi et al Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. J Med Chem. 2011 Mar 24;54(6):1599-612.
- C Granchi et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org Biomol Chem. 2013 Oct 14;11(38):6588-96.
Other Categories
Get a Quote for
Loading...