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AGI 6780
Axon 2274
CAS:
1432660-47-3
Purity:
99%
- Soluble in DMSO
- MF: C21H18F3N3O3S2
- MW: 481.51
Description
Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2.
AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nM for reduction of 2HG levels in cell lines) in an allosteric manner at the dimer interface, and induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.
More Information
| Parent CAS No. | 1432660-47-3 |
|---|---|
| Chemical Name | N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide |
| SMILES | C12NC(=O)CC=1C=C(OC1C(C)=CC=C(NC(=O)C3C=C(C(F)(F)F)C(CN4CCN(CC)CC4)=CC=3)C=1)C=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C30H31F3N4O3/c1-3-36-10-12-37(13-11-36)18-21-6-5-20(15-25(21)30(31,32)33)29(39)34-23-7-4-19(2)27(17-23)40-24-8-9-26-22(14-24)16-28(38)35-26/h4-9,14-15,17H,3,10-13,16,18H2,1-2H3,(H,34,39)(H,35,38) |
| InChiKey | AOZPVMOOEJAZGK-UHFFFAOYSA-N |
| CID | 71299339 |
| Short Description | IDH2 inhibitor |
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