Order

Size
Price
Stock
Qty

AG-221

 - Enasidenib
Axon 2745
Based on 15 publications in PubMed
CAS:  1446502-11-9
Purity:  99%
  • Soluble in DMSO
  • MF:  C19H17F6N7O
  • MW:  473.37

Description

AG-221 (Enasidenib) is an oral, selective, first-in-class inhibitor of the mutant IDH2 enzyme (IC50 value of 100 nM). AG-221 demonstrates excellent pharmaceutical properties, including adequate solubility, low clearance, and good oral bioavailability, and potently inhibits 2HG production by both the IDH2R140Q/WT heterodimer and IDH2R140Q homodimer. AG-221 suppressed 2HG production and induced cellular differentiation in primary human IDH2 mutation–positive acute myeloid leukaemia (AML) cells ex vivo and in xenograft mouse models.

More Information

Parent CAS No. 1446502-11-9
Chemical Name 2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol
SMILES N1C(C(F)(F)F)=CC(NC2N=C(C3C=CC=C(C(F)(F)F)N=3)N=C(NCC(C)(C)O)N=2)=CC=1
MFCD N.A.
InChi InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
InChiKey DYLUUSLLRIQKOE-UHFFFAOYSA-N
CID 89683805
Short Description IDH2 inhibitor

Related Products

AXON ID NAME FROM PRICE
2122 AGI 5198

From $66.00

2274 AGI 6780

From $99.00

2746 AG-120

From $137.50

4024 Vorasidenib

From $154.00

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

Loading...