Bulk Inquiry
AG-120
- Ivosidenib
- Optical Purity: 99.9% e.e.
- Soluble in DMSO
- MF: C28H22ClF3N6O3
- MW: 582.96
Description
AG-120 (Ivosidenib) is an orally active and selective inhibitor of oncogenic mutant isocitrate dehydrogenase 1 (IDH1). It blocks the neomorphic conversion of α-ketoglutarate to D-2-hydroxyglutarate (2-HG), lowering intracellular 2-HG in cells carrying IDH1 R132 mutations.
In mutant-IDH1 cellular and primary blast models, AG-120 suppresses growth-factor-independent proliferation and restores lineage differentiation. It is a well-characterized tool for investigating mutant-IDH1 metabolism, epigenetic dysregulation and differentiation in hematologic and solid-tumor systems.
Key Features
- Selective mutant-IDH1 inhibitor
- Reduces D-2-hydroxyglutarate production
- Restores differentiation in IDH1-mutant cells
- Orally active compound
Applications
- Mutant IDH1 enzymology
- 2-HG and oncometabolite studies
- AML differentiation research
- Cancer epigenetics
- IDH1-mutant tumor models
More Information
| Parent CAS No. | 1448347-49-6 |
|---|---|
| Chemical Name | (S)-N-((S)-1-(2-chlorophenyl)-2-(3,3-difluorocyclobutylamino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| SMILES | C1C(N(C([C@@H]2CCC(=O)N2C2N=CC=C(C#N)C=2)=O)[C@H](C(NC2CC(F)(F)C2)=O)C2C=CC=CC=2Cl)=CN=CC=1F |&1:4,19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1 |
| InChiKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
| CID | 71657455 |
| Short Description | IDH1 inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 2122 | AGI 5198 |
From $66.00 |
| 2274 | AGI 6780 |
From $99.00 |
| 2745 | AG-221 |
From $104.50 |
| 3863 | BAY-1436032 |
From Inquiry |
| 4024 | Vorasidenib |
From $154.00 |
