Bulk Inquiry
AGI 5198
- IDH-C35
- Soluble in DMSO
- MF: C27H31FN4O2
- MW: 462.56
Description
AGI 5198 (IDH-C53) is a potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), with selectivity for IDH1 R132H and R132C mutants and reported in vitro IC50 values of 0.07 and 0.16 µM. It inhibits production of the oncometabolite 2-hydroxyglutarate.
Mutant IDH1 alters cellular metabolism, epigenetic state and differentiation in glioma and other cancers. AGI 5198 is pharmacologically relevant for studying IDH1-mutant tumor biology and metabolic reprogramming.
Key Features
- Selective inhibitor of mutant IDH1 enzymes
- Active against IDH1 R132H and R132C variants
- Suppresses 2-hydroxyglutarate production
- Useful oncometabolism probe
Applications
- IDH1-mutant cancer research
- 2-Hydroxyglutarate measurement assays
- Glioma and leukemia model studies
- Cancer metabolism and epigenetic regulation research
More Information
| Parent CAS No. | 1355326-35-0 |
|---|---|
| Chemical Name | N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide |
| SMILES | C1(C)N(CC(N(C(C2=CC=CC=C2C)C(NC2CCCCC2)=O)C2=CC=CC(F)=C2)=O)C=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34) |
| InChiKey | FNYGWXSATBUBER-UHFFFAOYSA-N |
| CID | 56645356 |
| Short Description | IDH1 inhibitor |
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1756 | BVT 2733 hydrochloride |
From $99.00 |
| 2125 | CPI-613 |
From $121.00 |
| 2274 | AGI 6780 |
From $99.00 |
| 2450 | NHI 2 |
From $99.00 |
| 2476 | DEAB |
From $55.00 |
| 2551 | Alda 1 |
From $71.50 |
| 2745 | AG-221 |
From $104.50 |
| 2746 | AG-120 |
From $137.50 |
| 3863 | BAY-1436032 |
From Inquiry |
| 4024 | Vorasidenib |
From $154.00 |
