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GSK2837808A
Axon 3621
CAS:
1445879-21-9
Purity:
98%
- Soluble in DMSO
- MF: C31H25F2N5O7S
- MW: 649.62
Description
GSK2837808A is a potent, selective and NADH-competitive inhibitor of LDH-A with an IC50 value of 0.0026 μM.
More Information
| Parent CAS No. | 1445879-21-9 |
|---|---|
| Chemical Name | 3-(3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-ylamino)-5-(3,5-difluorophenoxy)benzoic acid |
| SMILES | C1(OC)N=CC(C2C=C3N=CC(S(=O)(=O)NC4CC4)=C(NC4C=C(C(O)=O)C=C(OC5C=C(F)C=C(F)C=5)C=4)C3=CC=2)=C(OC)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C31H25F2N5O7S/c1-43-29-25(14-35-31(37-29)44-2)16-3-6-24-26(9-16)34-15-27(46(41,42)38-20-4-5-20)28(24)36-21-7-17(30(39)40)8-22(13-21)45-23-11-18(32)10-19(33)12-23/h3,6-15,20,38H,4-5H2,1-2H3,(H,34,36)(H,39,40) |
| InChiKey | RZBCPMYJIARMGV-UHFFFAOYSA-N |
| CID | 71533725 |
| Short Description | LDH-A inhibitor |
References
- J Billiard et al. Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer Metab. 2013 Sep 6;1(1):19.
- D Annas et al. Synthesis and initial screening of lactate dehydrogenase inhibitor activity of 1,3-benzodioxole derivatives. Sci Rep. 2020 Nov 16;10(1):19889.
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