Glucokinase

The glucose-phosphorylating enzyme glucokinase (GK; EC 2.7.1.2) was identified as an outstanding drug target for developing antidiabetic medicines because it has an exceptionally high impact on glucose homeostasis because of its glucose sensor role in pancreatic β-cells and as a rate-controlling enzyme for hepatic glucose clearance and glycogen synthesis, both processes that are impaired in type 2 diabetes[1]. GK facilitates the phosphorylation of glucose to glucose-6-phosphate (G6P), which is the first step of both glycogen synthesis and glycolysis.


[1] Glucokinase Activators for Diabetes Therapy. Diabetes Care 2011, 34, S236-S243

3 Item(s)

per page
Axon ID Name Description From price
1134 RO 28-0450 Glucokinase (GK) activator €125.00
1355 RO 28-1674 Glucokinase (GK) activator €125.00
1356 RO 28-1675 Glucokinase (GK) activator €105.00

3 Item(s)

per page
Please wait...