ATPase (Ca2+)

Ca2+-ATPases (EC 3.6.3.8) are key actors in the regulation of Ca2+ in eukaryotic cells and are thus essential to the correct functioning of the cell machinery. They have high affinity for Ca2+ and can efficiently regulate it down to very low concentration levels. Three Ca2+-ATPase pumps are known, which are SERCA, PMCA and SPCA. Most of the pump defects described so far are genetic: when they are very severe, they produce gross and global disturbances of Ca2+ homeostasis that are incompatible with cell life. However, pump defects may also be of a type that produce subtler, often tissue-specific disturbances that affect individual components of the Ca2+-controlling and/or processing machinery. They do not bring cells to immediate death but seriously compromise their normal functioning.[1]


[1] M. Brini et al. Calcium pumps in health and disease. Physiol Rev. 2009 Oct;89(4):1341-78.

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Axon ID Name Description From price
2684 CDN1163 Allosteric Activator of SERCA2b  Recently added €90.00

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