MAGL

MAGL

Monoacylglycerol lipase (MAGL; EC 3.1.1.23) is the principal enzyme responsible for the in vivo degradation of 2-arachidonoyl glycerol (2-AG), an endogenous ligand of the cannabinoid receptors. Two other enzymes that participate in the breakdown of 2-AG are α/β-hydrolase domain-containing 6 (ABHD6) and α/β-hydrolase domain-containing 12 (ABHD12). It has been hypothesized that inhibition of MAGL may represent a useful and novel approach for the treatment of neuropathic pain, anxiety and inflammatory bowel diseases, vomiting, and nausea, as well as against the proliferation and migration of cancer cells.

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More About MAGL

Monoacylglycerol lipase (MAGL; EC 3.1.1.23) is the principal enzyme responsible for the in vivo degradation of 2-arachidonoyl glycerol (2-AG), an endogenous ligand of the cannabinoid receptors. Two other enzymes that participate in the breakdown of 2-AG are α/β-hydrolase domain-containing 6 (ABHD6) and α/β-hydrolase domain-containing 12 (ABHD12). It has been hypothesized that inhibition of MAGL may represent a useful and novel approach for the treatment of neuropathic pain, anxiety and inflammatory bowel diseases, vomiting, and nausea, as well as against the proliferation and migration of cancer cells[1].

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