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ABX-1431
Axon 3000
CAS:
1446817-84-0
Purity:
98%
- Soluble in DMSO
- MF: C20H22F9N3O2
- MW: 507.39
Description
ABX-1431 is a highly potent, selective, and orally available, CNS-penetrant MGLL (MAGL) inhibitor with an IC50 value of 0.014 µM. In vivo, ABX-1431 inhibits MGLL activity in rodent brain (ED50 value of 0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.
More Information
| Parent CAS No. | 1446817-84-0 |
|---|---|
| Chemical Name | 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)piperazine-1-carboxylate |
| SMILES | C1C=C(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)C(N2CCCC2)=CC=1C(F)(F)F |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2 |
| InChiKey | SQZJGTOZFRNWCX-UHFFFAOYSA-N |
| CID | 71657619 |
| Short Description | MAGL inhibitor |
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