Esterases (Carboxyl)

Phospholipases and acetylcholinesterases are members of the subclass of esterases. Hydrolyzing phospholipids into a carboxylic acid and a lysophospholipid, the PLA1 and PLA2 (EC esterases differentiate from PLC and PLD which are responsible for cleaving either sites of the phophonate bonds present in phospholipids. Due to the importance of PLA2 in inflammatory responses, regulation of the enzyme is essential. PLA2 is regulated by phosphorylation and calcium concentrations. PLA2 is phosphorylated by a MAPK at Serine-505. When phosphorylation is coupled with an influx of calcium ions, PLA2 becomes stimulated and can translocate to the membrane to begin catalysis.[1]

[1] Properties and Regulation of Cytosolic Phospholipase A2. C.C. Leslie. J. Biol. Chem. 1997, 272, 16709-16712.

22 Item(s)

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Axon ID Name Description From price
3000 ABX-1431 Highly potent, selective, brain-penetrant, and orally available MAGL inhibitor €135.00
3682 AMZ30 Potent, selective and covalent PME-1 inhibitor €130.00
2578 ASB14780 Potent, orally available inhibitor of cPLA2α; antiinflammatory drug €130.00
2276 Atglistatin Potent and selective inhibitor of adipose triglyceride lipase (ATGL) €90.00
2661 AZD2716 Potent secreted phospholipase A2 (sPLA2) inhibitor €145.00
3297 BChE inhibitor 8012-9656 Highly potent, selective and brain-penetrant BChE inhibitor €140.00
1609 CDIBA cPLA2 inhibitor €125.00
3478 Dehydroevodiamine hydrochloride Potent acetylcholinesterase inhibitor €70.00
2982 DO264 Potent, selective, and in vivo active ABHD12 inhibitor €125.00
1438 Donepezil hydrochloride Acetylcholinesterase inhibitor €60.00
3707 GLN-1062 Brain-pentrant prodrug of galantamine; Acetylcholinesterase inhibitor €120.00
3213 GSK264220A Potent endothelial lipase (EL) and lipoprotein lipase (LPL) inhibitor €90.00
2486 JZP 361 Selective reversible inhibitor of MAGL with Histamine H1 antagonistic activity €125.00
2797 Lalistat 2 Selective inhibitor of lysosomal acid lipase (LAL) €105.00
3296 LEI-301 Potent phospholipase A and acyltransferase (PLAAT) inhibitor €140.00
2580 MJN110 Potent, selective, and in-vivo-active MAGL inhibitor €85.00
3658 Neostigmine methyl sulfate Reversible acetylcholinesterase inhibitor €40.00
3500 Orlistat Potent, specific and irreversible inhibitor of pancreatic and gastric lipases €120.00
3167 Rivastigmine tartrate Centrally selective acetylcholinesterase inhibitor €60.00
2696 URB602 Non-competitive inhibitor of MAGL €60.00
4077 Varespladib sPLA2 inhibitor Inquire
4032 Varespladib methyl Secretory phospholipase A2 (sPLA2) inhibitor Inquire

22 Item(s)

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