Acetylcholinesterase (AChE; EC 188.8.131.52), a type of serine proteases, is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission, thereby playing a fundamental role in acetylcholine mediated neurotransmission. Blockade of AChE results in elevated concentrations of acetylcholine in the synaptic cleft with the potential to cause muscular paralysis, convulsions, bronchial constriction, and death by asphyxiation. The gradual loss of AChE activity is hypothesized to be the main cause of Alzheimer’s disease, as AChE in healthy organisms plays a key role in the assembly of amyloid fiber. Additionally, it has been shown that the main active ingredient in cannabis, tetrahydrocannibinol, is a competitive inhibitor of acetylcholinesterase.
 Acetylcholinesterase — new roles for an old actor. H. Soreq, S. Seidman. Nat. Rev. Neurosc. 2001, 2, 294-302.
 A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology. L.M. Eubanks et al. Mol Pharm. 2006, 3, 773-777.