Endothelial lipase (LIPG) plays an essential role in regulating lipid metabolism and the inflammatory response. Hydrolysis of HDL by LIPG decreases HDL-C levels, which promotes inflammation through multiple mechanisms such as adhesion of monocytes to the endothelium through downregulation of adhesion molecule VCAM-1, and upregulation of pro-inflammatory factors IL-6 and IL-12. Furthermore, LIPG activity provides extracellular lipid precursors for intracellular lipid biosynthesis, which contributes to cell growth and proliferation. Therefore, in addition to its potential therapeutic role in metabolic diseases like atherogenesis and diabetes, LIPG poses an exciting and new opportunity for cancer therapy[1].

[1] JE Yu et al. The role of endothelial lipase in lipid metabolism, inflammation, and cancer. Histol Histopathol. 2018 Jan;33(1):1-10.