ATPase (AAA+)
Complex cellular events commonly depend on the activity of molecular "machines" that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An essential and expanding subset of these assemblies comprises proteins of the ATPases associated with diverse cellular activities (AAA+) family. The defining feature of AAA+ proteins is a structurally conserved ATP-binding module that oligomerizes into active arrays. ATP binding and hydrolysis events at the interface of neighboring subunits drive conformational changes within the AAA+ assembly that direct translocation or remodeling of target substrates.[1]
[1] JP Erzberger et al. Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct. 2006;35:93-114.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
3216 | DCZ0415 | AAA-ATPase TRIP13 inhibitor | €85.00 | |
3581 | ONC212 | TRAIL inducer; Selective GPR132 agonist | Recently added | €110.00 |
2663 | Rbin-1 | Potent, reversible, and specific inhibitor of Midasin | €125.00 | |
2712 | Rbin-2 | Potent, reversible, and specific inhibitor of Midasin | €95.00 |