ATPase (AAA+)

Complex cellular events commonly depend on the activity of molecular "machines" that efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An essential and expanding subset of these assemblies comprises proteins of the ATPases associated with diverse cellular activities (AAA+) family. The defining feature of AAA+ proteins is a structurally conserved ATP-binding module that oligomerizes into active arrays. ATP binding and hydrolysis events at the interface of neighboring subunits drive conformational changes within the AAA+ assembly that direct translocation or remodeling of target substrates.[1]


[1] JP Erzberger et al. Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu Rev Biophys Biomol Struct. 2006;35:93-114.

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Axon ID Name Description From price
3216 DCZ0415 AAA-ATPase TRIP13 inhibitor €85.00
3581 ONC212 TRAIL inducer; Selective GPR132 agonist  Recently added €110.00
2663 Rbin-1 Potent, reversible, and specific inhibitor of Midasin €125.00
2712 Rbin-2 Potent, reversible, and specific inhibitor of Midasin €95.00

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