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Rbin-2

 - Ribozinoindole-2
Axon 2712
CAS:  2032282-97-4
Purity:  98%
  • Soluble in DMSO
  • MF:  C13H11BrN4S
  • MW:  335.22

Description

Rbin-2 (ribozinoindole-2) is a potent, reversible, and selective inhibitor of the essential AAA+ ATPase Midasin (Mdn1/Rea1), with a reported GI50 of 14 nM in wild-type cells. Rbin-2 directly inhibits Mdn1 ATPase function, preventing the ATP-dependent removal of assembly factors from pre-60S ribosomal particles.

Acute Mdn1 inhibition disrupts large-ribosomal-subunit maturation, nucleolar organization, and production of functional ribosomes without requiring genetic depletion of this essential enzyme. Rbin-2 is therefore a powerful chemical probe for temporal studies of eukaryotic ribosome biogenesis and AAA+ mechanoenzyme function. The related Midasin inhibitor Rbin-1 (Axon 2663) is also available.

Key Features

  • Potent reversible inhibitor of Midasin/Mdn1
  • GI50: 14 nM in wild-type cells
  • Directly inhibits an essential AAA+ ATPase
  • Blocks pre-60S ribosomal-subunit maturation
  • Enables rapid, reversible perturbation of ribosome assembly

Applications

  • Eukaryotic ribosome biogenesis
  • Midasin/Mdn1 ATPase mechanism
  • Pre-60S ribosomal-particle maturation
  • Nucleolar function and organization
  • AAA+ mechanoenzyme research

More Information

Parent CAS No. 2032282-97-4
Chemical Name 7-Bromo-3-(2-methylallylthio)-5H-[1,2,4]triazino[5,6-b]indole
SMILES C1C=C2C3N=NC(SCC(C)=C)=NC=3NC2=CC=1Br
MFCD N.A.
InChi InChI=1S/C13H11BrN4S/c1-7(2)6-19-13-16-12-11(17-18-13)9-4-3-8(14)5-10(9)15-12/h3-5H,1,6H2,2H3,(H,15,16,18)
InChiKey OVDAOBDZJJZJMY-UHFFFAOYSA-N
CID 129909865
Short Description Midasin inhibitor

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