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Rbin-1

 - Ribozinoindole-1
Axon 2663
CAS:  328023-11-6
Purity:  99%
  • Soluble in DMSO
  • MF:  C13H12N4S
  • MW:  256.33

Description

Rbin-1 (ribozinoindole-1) is a potent, reversible inhibitor of the AAA+ ATPase Midasin (Mdn1), showing a GI of 136 nM in wild-type cells. It successfully blocks eukaryotic ribosome assembly.

Rbin-1 is a chemical probe that supports mechanistic investigations into Midasin- and ATP-dependent pathways in cellular and translational research models.

Key Features

  • High Potency: Inhibits wild-type cell growth with a GI₅₀ of 136 nM
  • Target Specificity: Selectively targets Midasin (Mdn1) over other AAA+ ATPases
  • Reversible Action: Enables transient inhibition and washout recovery studies
  • Eukaryotic Tool: Validated for studying eukaryotic ribosome assembly machinery

Applications

  • Ribosome Biogenesis
  • AAA+ ATPase Profiling
  • Translational Disease Modeling
  • Genetic Resistance Mapping

Note: Midasin inhibitor Rbin-2 (Axon 2712) is also available.

More Information

Parent CAS No. 328023-11-6
Chemical Name 3-(2-Methylallylthio)-5H-[1,2,4]triazino[5,6-b]indole
SMILES C1C=C2C3N=NC(SCC(C)=C)=NC=3NC2=CC=1
MFCD N.A.
InChi InChI=1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H,1,7H2,2H3,(H,14,15,17)
InChiKey LPCWHNSRTRBKBO-UHFFFAOYSA-N
CID 5731061
Short Description Midasin inhibitor

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